Optic Nerve Coloboma Vs Morning Glory

Optic nerve colobomas also lack the central glial tuft and peripapillary pigmentation seen in morning glory disc anomalies.

Optic nerve coloboma vs morning glory. The etiology of morning glory disc anomaly is poorly understood. An optic nerve coloboma is easily differentiated from morning glory anomaly. It is important to differentiate from a morning glory disc anomaly because optic nerve colobomas can be associated with systemic syndromes such as charge coloboma of the eye heart defects choanal atresia growth. Thus the morning glory disc is sometimes misdiagnosed as an optic nerve coloboma.

Remarkably a myriad of morphologic variations of phenotype were expressed including optic disc pits morning glory syndrome and coloboma of the optic nerve. 2 retinal manifestations of morning glory disc syndrome. Morning glory disc anomaly is almost universally a sporadic condition whereas optic nerve coloboma is commonly familial and may occur in association with multisystem congenital malformation syndromes 1. Morning glory disc anomaly mgda is a clinically distinct condition from optic nerve coloboma.

There are some similarities to optic disc coloboma with interference in the closure of the posterior aspect of the fetal fissure. One gene defect can result in a variety of optic disc abnormalities. Patients typically have excavated conical optic disc central glial tuft retinal vessels that exit radially from the enlarged posterior scleral opening and peripapillary pigment. Optic disc coloboma the morning glory syndrome and optic nerve coloboma associated with transsphenoidal meningoencephalocele european journal of radiology extra vol.

Colobomas affect only the inferior aspect of the nerve as it represents an incomplete closure of the embryonic fissure whereas mgda encompasses all aspects of the nerve and represents more generally a dysgenesis of the mesoderm.